• Team

Featured articles

Below you will find links to some of our COMPATH team’s latest articles

Acta Neuropathol Commun 2019 doi: 10.1186/s40478-019-0660-3

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Canc Res 2018 doi: 10.1158/0008-5472.CAN-18-0912

Induction of Paracrine Signaling in Metastatic Melanoma Cells by PPARγ Agonist Rosiglitazone Activates Stromal Cells and Enhances Tumor Growth

Nat Commun 2018 doi:10.1038/s41467-018-07130-z

Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion

Nature 2018 doi: 10.1038/s41586-018-0645-6

De novo NAD+ synthesis enhances mitochondrial function and improves health

Frontiers in Behavioral Neuroscience 2018 doi.org/10.3389/fnbeh.2018.00232

Effects of Cage Enrichment on Behavior, Welfare and Outcome Variability in Female Mice

International Journal  for Parasitology: Drugs and Drug Resistance 2018 doi.org/10.1016/j.ijpddr.2018.06.004

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis

Cancer Cell 2018 doi: 10.1016/j.ccell.2018.05.008

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Cell reports 2018 doi: 10.1016/j.celrep.2018.04.046

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

Cancer Cell 2018  doi: 10.1016/j.ccell.2018.02.011

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

Nat Methods 2018  doi: 10.1038/nmeth.4535.

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

Cell reports 2017 DOI: https://doi.org/10.1016/j.celrep.2017.11.052

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nat Cell Biol 2017  doi: 10.1038/ncb3626.

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

Clin Cancer Res 2017 doi: 10.1158/1078-0432.CCR-17-1279.

Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

Nat Commun 2017  doi: 10.1038/ncomms15981.

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Nature 2016 doi: 10.1038/nature18325.

Replication fork stability confers chemoresistance in BRCA-deficient cells.

Nature 2015 doi:10.1038/nature14328.

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Cancer Res. 2015 doi: 10.1158/0008-5472.CAN-14-0839.

BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance.

Cardiovasc Res. 2015 Feb 1;105(2):213-22. doi: 10.1093/cvr/cvu257. Epub 2014 Dec 23.

Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation.